Nature

Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury

Preclinical investigations into the role of complement in closed-head TBI are somewhat limited. To our knowledge, no studies have examined the role of complement in repetitive mild closed head injury ...
Nature

Inflammatory transcriptomic signatures in a human cellular NMOSD model reveal upregulation of NF-κB and IL6 pathways

Neuromyelitis optica spectrum disorder (NMOSD) is a rare neurological autoimmune disease caused by autoantibodies targeting the astrocytic water channel aquaporin-4 (AQP4). Binding to AQP4 initiates ...
Healio

Alternative complement pathway inhibition may be key to lupus management

Please provide your email address to receive an email when new articles are posted on . Kim’s hypothesis arises partially from studies that showed that C3, when introduced to synthetic neutrophils, ...
PharmTech

Implications of FDA Granting Priority Review to AZ's Ravulizumab

Priority review for ravulizumab in IgA nephropathy could establish the first C5 complement inhibitor label in this indication, addressing substantial residual progression risk despite current standard ...